Article
Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function.
Trends in endocrinology and metabolism: TEM - 1 Aug 2003
Hu Jianxin, Spiegel Allen M
Abstract excerpt
The extracellular Ca2+-sensing receptor is a member of the G-protein-coupled receptor family 3 in which agonists bind to a dimeric Venus-flytrap domain in the extracellular portion of the receptor. How agonist binding to this domain leads to activation of the seven-transmembrane domain is a major unresolved question. Information derived from the three-dimensional structure of the Venus-flytrap domain of the...
Topics
- Amino Acid Sequence
- Extracellular Space
- Humans
- Models, Structural
- Molecular Sequence Data
- Mutation
- Receptors, Calcium-Sensing
- Structure-Activity Relationship