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Article

Increased platelet activation and thrombosis in transgenic mice expressing constitutively active P2Y12.

Journal of thrombosis and haemostasis : JTH - 1 Oct 2012

Zhang Y, Ye J, Hu L, Zhang S, Zhang S H, Li Y, Kunapuli S P, Ding Z

Abstract excerpt

BACKGROUND: In our previous in vitro study, we reported a constitutively active chimeric P2Y(12) (cP2Y(12)) and found that AR-C78511 is a potent inverse agonist at this receptor. The role of cP2Y(12) in platelet activation and thrombosis is not clear. OBJECTIVES: To investigate the physiologic implications of cP2Y(12) for platelet activation and thrombus formation, and to evaluate the antiplatelet activity of...

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Identifiers

PMID: 22906019
DOI: 10.1111/j.1538-7836.2012.04894.x
PMCID: PMC3495164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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