Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B and FMTC: two novel mutations and one de novo mutation for MEN 2A.

doi:10.1007/BF00218825

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Article

Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B and FMTC: two novel mutations and one de novo mutation for MEN 2A.

Human genetics - 1 Jan 1996

Landsvater R M, Jansen R P, Hofstra R M, Buys C H, Lips C J, Ploos van Amstel H K

Abstract excerpt

Hereditary C-cell carcinoma is encountered in multiple endocrine neoplasia type 2A (MEN 2A), MEN 2B, and familial medullary thyroid carcinoma (FMTC). Mutations of the RET proto-oncogene are associated with all three diseases. To obtain an insight into the molecular heterogeneity of MEN 2 syndrome...

Topics

Amino Acid Sequence
Base Sequence
Carcinoma, Medullary
DNA Mutational Analysis
DNA Primers
Drosophila Proteins
Exons
Humans
Molecular Sequence Data
Multiple Endocrine Neoplasia Type 2a
Multiple Endocrine Neoplasia Type 2b

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Netherlands

Point Mutation

Polymerase Chain Reaction

Proto-Oncogene Mas

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-ret

Source

Open in PubMed

Identifiers

PMID: 8557249
DOI: 10.1007/BF00218825

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8557249-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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