A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.

doi:10.1038/367375a0

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Article

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.

Nature - 27 Jan 1994

Hofstra R M, Landsvater R M, Ceccherini I, Stulp R P, Stelwagen T, Luo Y, Pasini B, Höppener J W, van Amstel H K, Romeo G

Abstract excerpt

Multiple endocrine neoplasia type 2 (MEN 2) comprises three clinically distinct, dominantly inherited cancer syndromes. MEN 2A patients develop medullary thyroid carcinoma (MTC) and phaeochromocytoma. MEN 2B patients show in addition ganglioneuromas of the gastrointestinal tract and skeletal abnormalities. In familial MTC, only the thyroid is affected. Germ-line mutations of the RET proto-oncogene have recently...

Topics

Base Sequence
Carcinoma, Medullary
Codon
DNA Primers
Drosophila Proteins
Exons
Female
Humans
Male
Molecular Sequence Data
Multiple Endocrine Neoplasia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Point Mutation

Polymerase Chain Reaction

Polymorphism, Genetic

Proto-Oncogene Mas

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-ret

Source

Open in PubMed

Identifiers

PMID: 7906866
DOI: 10.1038/367375a0

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7906866-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.PMID 7906866Read ↗

RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma.Semantic proximity Read ↗

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B.Semantic proximity Read ↗

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.Semantic proximity Read ↗

Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B and FMTC: two novel mutations and one de novo mutation for MEN 2A.Semantic proximity Read ↗

Somatic and MEN 2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTC:s.Semantic proximity Read ↗

RET proto-oncogene mutations in French MEN 2A and FMTC families.Semantic proximity Read ↗

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Multiple endocrine neoplasias type 2B and RET proto-oncogene.Semantic proximity Read ↗

Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and hirschsprung disease.Semantic proximity Read ↗

Germline Dinucleotide Mutation in Codon 883 of the RETProto-Oncogene in Multiple Endocrine Neoplasia Type 2B Without Codon 918 MutationSemantic proximity Read ↗

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