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Article

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC

1 Jan 1993

Abstract excerpt

Multiple endocrine neoplasia type 2A (MEN 2A) and familial medullary thyroid carcinoma (FMTC) are dominantly inherited conditions which predispose to the development of endocrine neoplasia. Evidence is presented that sequence changes within the coding region of the RET proto-oncogene, a putative transmembrane tyrosine kinase, may be responsible for the development of neoplasia in these inherited disorders. Single...

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Identifiers

PMID: 8103403
DOI: 10.1093/hmg/2.7.851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTCPMID 8103403Read ↗

Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC.Semantic proximity Read ↗

Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B and FMTC: two novel mutations and one de novo mutation for MEN 2A.Semantic proximity Read ↗

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.Semantic proximity Read ↗

Molecular implications of RET mutations for pheochromocytoma risk in multiple endocrine neoplasia 2.Semantic proximity Read ↗

RET proto-oncogene mutations in French MEN 2A and FMTC families.Semantic proximity Read ↗

RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma.Semantic proximity Read ↗

RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors.Semantic proximity Read ↗

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

Analysis of RET proto-oncogene abnormalities in patients with MEN 2A, MEN 2B, familial or sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

RET gene mutations (genotype and phenotype) of multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma.Semantic proximity Read ↗

RET proto-oncogene in the development of human cancer.Semantic proximity Read ↗

The Relationship Between Specific RET Proto-oncogene Mutations and Disease Phenotype in Multiple Endocrine Neoplasia Type 2Semantic proximity Read ↗

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