Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

doi:10.1038/363458a0

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Article

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

Nature - 3 Jun 1993

Mulligan L M, Kwok J B, Healey C S, Elsdon M J, Eng C, Gardner E, Love D R, Mole S E, Moore J K, Papi L

Abstract excerpt

Multiple endocrine neoplasia type 2A (MEN 2A) is a dominantly inherited cancer syndrome that affects tissues derived from neural ectoderm. It is characterized by medullary thyroid carcinoma (MTC) and phaeochromocytoma. The MEN2A gene has recently been localized by a combination of genetic and phy...

Topics

Amino Acid Sequence
Base Sequence
Carcinoma
Codon
Cysteine
DNA Mutational Analysis
DNA, Neoplasm
DNA, Single-Stranded
Drosophila Proteins
Germ Cells
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Multiple Endocrine Neoplasia

Mutation

Pheochromocytoma

Polymerase Chain Reaction

Protein-Tyrosine Kinases

Source

Open in PubMed

Identifiers

PMID: 8099202
DOI: 10.1038/363458a0

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8099202-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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