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Article

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.

Nature - 3 Jun 1993

Mulligan L M, Kwok J B, Healey C S, Elsdon M J, Eng C, Gardner E, Love D R, Mole S E, Moore J K, Papi L

Abstract excerpt

Multiple endocrine neoplasia type 2A (MEN 2A) is a dominantly inherited cancer syndrome that affects tissues derived from neural ectoderm. It is characterized by medullary thyroid carcinoma (MTC) and phaeochromocytoma. The MEN2A gene has recently been localized by a combination of genetic and physical mapping techniques to a 480-kilobase region in chromosome 10q11.2 (refs 2,3). The DNA segment encompasses the RET...

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Source

Identifiers

PMID: 8099202
DOI: 10.1038/363458a0

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.PMID 8099202Read ↗

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours.Semantic proximity Read ↗

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

RET proto-oncogene mutations in multiple endocrine neoplasia type 2 and medullary thyroid carcinoma.Semantic proximity Read ↗

Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B.Semantic proximity Read ↗

Molecular implications of RET mutations for pheochromocytoma risk in multiple endocrine neoplasia 2.Semantic proximity Read ↗

RET proto-oncogene mutations in French MEN 2A and FMTC families.Semantic proximity Read ↗

RET proto-oncogene in the development of human cancer.Semantic proximity Read ↗

Mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2.Semantic proximity Read ↗

Mutational analysis of multiple endocrine neoplasia type 2A associated with Hirschsprung's disease.Semantic proximity Read ↗

Mutation analysis of the RET proto-oncogene in Dutch families with MEN 2A, MEN 2B and FMTC: two novel mutations and one de novo mutation for MEN 2A.Semantic proximity Read ↗

The RET E616Q Variant is a Gain of Function Mutation Present in a Family with Features of Multiple Endocrine Neoplasia 2A.Semantic proximity Read ↗

Mutations of the RET proto-oncogene in the multiple endocrine neoplasia type 2 syndromes, related sporadic tumours, and hirschsprung disease.Semantic proximity Read ↗

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