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Article

Double germline mutations in the RET Proto-oncogene in MEN 2A and MEN 2B kindreds.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Apr 2006

Dvorakova S, Vaclavikova E, Ryska A, Cap J, Vlcek P, Duskova J, Kodetova D, Holub V, Novak Z, Bendlova B

Abstract excerpt

Medullary thyroid carcinoma (MTC) is a rare form of thyroid cancer representing about 10% of all thyroid malignancies. It occurs mostly as a sporadic tumor or in association with autosomal dominant inherited cancer syndromes--multiple endocrine neoplasia (MEN) types 2A and 2B and familial MTC. Germline mutations in exons 8, 10, 11, 13, 14, 15 and 16 of the RET proto-oncogene are found in most of the familial...

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Source

Identifiers

PMID: 16705552
DOI: 10.1055/s-2006-924071

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Double germline mutations in the RET Proto-oncogene in MEN 2A and MEN 2B kindreds.PMID 16705552Read ↗

A RET double mutation in the germline of a kindred with FMTC.Semantic proximity Read ↗

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Multiple endocrine neoplasia type 2A in two families with the familial medullary thyroid carcinoma associated G533C mutation of the RET proto-oncogene.Semantic proximity Read ↗

Two Germline Missense Mutations at Codons 804 and 806 of the <i>RET</i> Proto‐oncogene in the Same Allele in a Patient with Multiple Endocrine Neoplasia Type 2B without Codon 918 MutationSemantic proximity Read ↗

Multiple endocrine neoplasia type 2A due to an exon 8 (G533C) mutation in a large North American kindred.Semantic proximity Read ↗

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma.Semantic proximity Read ↗

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Germline Dinucleotide Mutation in Codon 883 of the<i>RET</i>Proto-Oncogene in Multiple Endocrine Neoplasia Type 2B Without Codon 918 MutationSemantic proximity Read ↗

RET proto-oncogene mutations are restricted to codon 634 and 618 in Korean families with multiple endocrine neoplasia 2A.Semantic proximity Read ↗

Three novel mutations in the RET proto-oncogene.Semantic proximity Read ↗

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