Article
Double germline mutations in the RET Proto-oncogene in MEN 2A and MEN 2B kindreds.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Apr 2006
Dvorakova S, Vaclavikova E, Ryska A, Cap J, Vlcek P, Duskova J, Kodetova D, Holub V, Novak Z, Bendlova B
Abstract excerpt
Medullary thyroid carcinoma (MTC) is a rare form of thyroid cancer representing about 10% of all thyroid malignancies. It occurs mostly as a sporadic tumor or in association with autosomal dominant inherited cancer syndromes--multiple endocrine neoplasia (MEN) types 2A and 2B and familial MTC. Germline mutations in exons 8, 10, 11, 13, 14, 15 and 16 of the RET proto-oncogene are found in most of the familial...
Topics
- Adolescent
- Adult
- Alleles
- Amino Acid Substitution
- Cohort Studies
- Exons
- Female
- Germ-Line Mutation
- Humans
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 2a
- Multiple Endocrine Neoplasia Type 2b