Enhanced sialic acid engagement at physiological temperatures by reovirus σ1 mutants facilitates infection of breast cancer cells with low levels of high-affinity receptors.

Abstract excerpt

Reovirus serotype 3 (T3DPL) serves as a safe, tractable model for studying fundamental virus-host interactions and is also under investigation as an oncolytic therapy. Many viruses, including reoviruses, use sialic acids as attachment factors in addition to protein receptors; however, the relative contributions of these interactions, particularly at physiological temperatures, remain poorly defined. T3DPL engages...

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