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Article

Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.

Science (New York, N.Y.) - 19 Jan 1996

Sanchez Y, Desany B A, Jones W J, Liu Q, Wang B, Elledge S J

Abstract excerpt

Mutants of the Saccharomyces cerevisiae ataxia telangiectasia mutated (ATM) homolog MEC1/SAD3/ESR1 were identified that could live only if the RAD53/SAD1 checkpoint kinase was overproduced. MEC1 and a structurally related gene, TEL1, have overlapping functions in response to DNA damage and replication blocks that in mutants can be provided by overproduction of RAD53. Both MEC1 and TEL1 were found to control...

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Source

Identifiers

PMID: 8553072
DOI: 10.1126/science.271.5247.357

Genes

ATM
ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways.PMID 8553072Read ↗

Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes.Semantic proximity Read ↗

The Hog1 MAP kinase pathway and the Mec1 DNA damage checkpoint pathway independently control the cellular responses to hydrogen peroxide.Semantic proximity Read ↗

Mutations in SPK1/RAD53 that specifically abolish checkpoint but not growth-related functions.Semantic proximity Read ↗

Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.Semantic proximity Read ↗

Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein HomeostasisSemantic proximity Read ↗

Activation of the budding yeast securin Pds1 but not Rad53 correlates with double-strand break-associated G2/M cell cycle arrest in a mec1 hypomorphic mutant.Semantic proximity Read ↗

A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1.Semantic proximity Read ↗

The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment.Semantic proximity Read ↗

Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function.Semantic proximity Read ↗

Non-catalytic function for ATR in the checkpoint response.Semantic proximity Read ↗

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast.Semantic proximity Read ↗

Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling.Semantic proximity Read ↗

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