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Article

Mutations in SPK1/RAD53 that specifically abolish checkpoint but not growth-related functions.

Current genetics - 1 Feb 1997

Fay D S, Sun Z, Stern D F

Abstract excerpt

SPK1/RAD53/SAD1/MEC2 encodes an essential protein kinase of Saccharomyces cerevisiae and is required for the execution of checkpoint arrest at multiple stages of the cell cycle. We have isolated two mutant alleles of SPK1 (spk1K227A and spk1-1A208P) that are defective for checkpoint-arrest functions but retain wild-type levels of SPK1-associated growth activity. Both mutations occur within conserved regions of...

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Source

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PMID: 9021124
DOI: 10.1007/s002940050181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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