Article
The Hog1 MAP kinase pathway and the Mec1 DNA damage checkpoint pathway independently control the cellular responses to hydrogen peroxide.
DNA repair - 2 Jul 2004
Haghnazari Edwin, Heyer Wolf-Dietrich
Abstract excerpt
The DNA damage checkpoint pathway and the MAP kinase pathway respond to various forms of environmental as well as endogenous stresses through signal transduction mechanisms involving protein kinases. Both pathways are intertwined in mammalian cells, but potential crosstalk between these two pathways in budding yeast has not been examined yet. We show that the Rad53 checkpoint kinase and the Hog1 MAP kinase of...
Topics
- Cell Cycle
- Cell Cycle Proteins
- Cell Survival
- Checkpoint Kinase 2
- DNA Damage
- DNA Repair
- DNA, Fungal
- Enzyme Activation
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal