Events in the endoplasmic reticulum abrogate the temperature sensitivity of Sindbis virus mutant ts23.

Abstract excerpt

Temperature-sensitive mutations in proteins produced at or heated to a nonpermissive temperature render the proteins defective in some aspect of their maturation into functional entities. The characterization of temperature-sensitive mutations in model proteins, such as virus membrane proteins, has allowed the elucidation of critical events in the maturation of virus membranes as well as in the intracellular...

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