Article
Mutations in an exposed domain of Sindbis virus capsid protein result in the production of noninfectious virions and morphological variants.
Virology - 1 Jul 1994
Lee H, Brown D T
Abstract excerpt
A critical event in the process of Sindbis virus assembly is the interaction of the virus nucleocapsid with the target membrane which has been modified by virus envelope glycoproteins. A specific association between the endodomain of the pE2/E2 glycoprotein and an unidentified domain in the capsid protein is responsible for this association. We have examined the nature of this association by the production of a...
Topics
- Amino Acid Sequence
- Animals
- Capsid
- Cell Line
- Cricetinae
- Culicidae
- Genetic Complementation Test
- Molecular Sequence Data
- Mutagenesis
- Phenotype
- Sindbis Virus
- Temperature