Article
Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus.
The Journal of cell biology - 1 Jul 1994
Hammond C, Helenius A
Abstract excerpt
Proteins synthesized in the ER are generally transported to the Golgi complex and beyond only when they have reached a fully folded and assembled conformation. To analyze how the selective retention of misfolded proteins works, we monitored the long-term fate of a membrane glycoprotein with a tem...
Topics
- Aluminum Compounds
- Animals
- Biological Transport
- CHO Cells
- Calcium-Binding Proteins
- Calnexin
- Carrier Proteins
- Cell Compartmentation
- Cell Fractionation
- Cricetinae
- Dithiothreitol
- Endoplasmic Reticulum
- Endoplasmic Reticulum Chaperone BiP
- Fluorescent Antibody Technique
- Fluorides
- Glycoproteins
- Golgi Apparatus
- Heat-Shock Proteins