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Article

The formation of intramolecular disulfide bridges is required for induction of the Sindbis virus mutant ts23 phenotype.

Journal of virology - 1 Oct 1997

Carleton M, Brown D T

Abstract excerpt

The Sindbis virus envelope protein spike is a hetero-oligomeric complex composed of a trimer of glycoprotein E1-E2 heterodimers. Spike assembly is a multistep process which occurs in the endoplasmic reticulum (ER) and is required for the export of E1 from the ER. PE2 (precursor to E2), however, can transit through the secretory pathway and be expressed at the cell surface in the absence of E1. Although oligomer...

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Identifiers

PMID: 9311853
DOI: 10.1128/JVI.71.10.7696-7703.1997
PMCID: PMC192120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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