Article
The reovirus mutant tsA279 has temperature-sensitive lesions in the M2 and L2 genes: the M2 gene is associated with decreased viral protein production and blockade in transmembrane transport.
Virology - 20 Feb 1995
Hazelton P R, Coombs K M
Abstract excerpt
Temperature-sensitive mutants provide an ideal means for dissecting viral assembly pathways. The morphological variants produced by and biological characteristics of tsA279, a previously uncharacterized mutant from the Fields' panel of temperature-sensitive mutants of reovirus, were determined un...
Topics
- Animals
- Capsid
- Capsid Proteins
- Cell Membrane
- Endosomes
- Genes, Viral
- Inclusion Bodies, Viral
- L Cells
- Mammalian orthoreovirus 3
- Mice
- Mutation
- Nucleotidyltransferases
- Organelles
- Orthoreovirus
- Reassortant Viruses
- Temperature
- Viral Core Proteins
- Viral Proteins