Article
Mutations in the v-mos gene abolish its ability to induce differentiation but not transformation.
European journal of cell biology - 1 Sept 1995
Kurata N, Akiyama H, Hosoya H, Aoki H, Ishikawa K, Marunouchi T
Abstract excerpt
The v-mos oncogene product has the ability to induce differentiation in human monocytic leukemia U937 cells, thereby arresting cell proliferation, and also exhibits transforming activity in mouse NIH3T3 cells. Mutation in the v-mos gene consisting of one or two amino acid substitutions in the putative ATP-binding domain impaired its differentiation-inducing activity although mutant proteins showed rather higher...
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