Article
Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67).
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 May 1996
Grant S, Freemerman A J, Birrer M J, Martin H A, Turner A J, Szabo E, Chelliah J, Jarvis W D
Abstract excerpt
The proto-oncogene c-jun encodes a component of the AP-1 transcription-activating complex and has been implicated in the regulation of diverse cellular processes, including cell proliferation, differentiation, transformation, and most recently, apoptosis. We have used a U937 monocytic leukemia ce...
Topics
- Antimetabolites, Antineoplastic
- Apoptosis
- Cell Cycle
- Cell Differentiation
- Cell Division
- Cytarabine
- Cytotoxins
- Gene Expression Regulation, Neoplastic
- Humans
- Leukemia, Promyelocytic, Acute
- Mutation
- Proto-Oncogene Mas
- Proto-Oncogene Proteins c-jun