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Article

Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells.

Cell and tissue research - 1 Jul 2011

Bertagnolo Valeria, Nika Ervin, Brugnoli Federica, Bonora Massimo, Grassilli Silvia, Pinton Paolo, Capitani Silvano

Abstract excerpt

Vav1 is a critical signal transducer for both the development and function of normal hematopoietic cells, in which it regulates the acquisition of maturation-related properties, including adhesion, motility, and phagocytosis. Vav1 is also important for the agonist-induced maturation of acute promyelocytic leukemia (APL)-derived promyelocytes, in which it promotes the acquisition of a mature phenotype by playing...

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PMID: 21647562
DOI: 10.1007/s00441-011-1195-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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