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Article

The MAPK ERK5, but not ERK1/2, inhibits the progression of monocytic phenotype to the functioning macrophage.

Experimental cell research - 1 Jan 2015

Wang Xuening, Pesakhov Stella, Harrison Jonathan S, Kafka Michael, Danilenko Michael, Studzinski George P

Abstract excerpt

Intracellular signaling pathways present targets for pharmacological agents with potential for treatment of neoplastic diseases, with some disease remissions already recorded. However, cellular compensatory mechanisms usually negate the initial success. For instance, attempts to interrupt aberrant signaling downstream of the frequently mutated ras by inhibiting ERK1/2 has shown only limited usefulness for cancer...

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Identifiers

PMID: 25447310
DOI: 10.1016/j.yexcr.2014.10.003
PMCID: PMC4364001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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