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Article

Interaction between the 5'-terminal cloverleaf and 3AB/3CDpro of poliovirus is essential for RNA replication.

Journal of virology - 1 Jun 1995

Xiang W, Harris K S, Alexander L, Wimmer E

Abstract excerpt

On the basis of sequence alignments and secondary structure comparisons of the first 100 nucleotides of enterovirus and rhinovirus RNAs, chimeric constructs in which this region of poliovirus type 1 Mahoney [PV1(M)] is replaced with that of human rhinovirus type 2 (HRV2) or HRV14 have been engineered. These chimeric constructs contain the internal ribosomal entry site of either poliovirus or encephalomyocarditis...

Topics

3C Viral Proteases
Base Sequence
Cysteine Endopeptidases
DNA Primers
HeLa Cells
Humans
Molecular Sequence Data
Nucleic Acid Conformation
Phenotype
Plasmids
Poliovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Biosynthesis

RNA, Viral

Viral Core Proteins

Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7745714
DOI: 10.1128/JVI.69.6.3658-3667.1995
PMCID: PMC189081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7745714-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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