Article
Isolation and characterization of a Chinese hamster ovary (CHO) mutant defective in the second step of glycosylphosphatidylinositol biosynthesis.
The Biochemical journal - 1 Jan 1996
Stevens V L, Zhang H, Harreman M
Abstract excerpt
Mutant cell lines defective in the biosynthesis of glycosylphosphatidylinositol (GPI) described to date were isolated by selecting cells which no longer expressed one or more endogenous GPI-anchored proteins on their surface. In this study, a new mutant in this pathway was isolated from ethylmeth...
Topics
- Acetylglucosamine
- Alkaline Phosphatase
- Animals
- CHO Cells
- Cricetinae
- DNA
- Genetic Complementation Test
- Glycosylphosphatidylinositols
- Humans
- Lymphoma
- Mice
- Mutation
- Phosphatidylinositols
- Placenta
- RNA, Messenger
- Thy-1 Antigens
- Transfection