Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective glycosyl phosphatidylinositol biosynthesis in extracts of three Thy-1 negative lymphoma cell mutants.

The Journal of biological chemistry - 5 Jun 1991

Stevens V L, Raetz C R

Abstract excerpt

The glycosyl phosphatidylinositol (GPI) anchors that attach certain proteins to membranes are preassembled by sequential addition of glycan components to phosphatidylinositol (PI) before being transferred to nascent polypeptide. A cell-free system consisting of trypanosome membranes has been reported to catalyze GPI biosynthesis (Masterson, W. J., Doering, T. L., Hart, G. W., and Englund, P. T. (1989) Cell 56,...

Topics

Animals
Autoradiography
Cell-Free System
Chromatography, Thin Layer
Glycolipids
Glycosylphosphatidylinositols
Lymphoma
Mutation
Phosphatidylinositols
Phospholipids
Trypanosoma brucei brucei

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 1828068

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1828068-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective glycosyl phosphatidylinositol biosynthesis in extracts of three Thy-1 negative lymphoma cell mutants.PMID 1828068Read ↗

Class F Thy-1-negative murine lymphoma cells are deficient in ether lipid biosynthesis.Semantic proximity Read ↗

Characterization of abnormal free glycophosphatidylinositols accumulating in mutant lymphoma cells of classes B, E, F, and H.Semantic proximity Read ↗

Atypical mannolipids characterize Thy-1-negative lymphoma mutants.Semantic proximity Read ↗

Isolation and characterization of a Chinese hamster ovary (CHO) mutant defective in the second step of glycosylphosphatidylinositol biosynthesis.Semantic proximity Read ↗

Biochemical analysis of glycophospholipids from wild-type mouse lymphoma cells and from Thy-1 negative mutants which do not add glycolipid-anchored proteins.Semantic proximity Read ↗

A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: topography of two GPI pathways.Semantic proximity Read ↗

Identification of defects in glycosylphosphatidylinositol anchor biosynthesis in the Thy-1 expression mutants.Semantic proximity Read ↗

Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in <i>Trypanosoma brucei</i>Semantic proximity Read ↗

Phosphatidylinositol-based glycolipid-anchored proteins enhance proximal TCR signaling events.Semantic proximity Read ↗

Affected paroxysmal nocturnal hemoglobinuria T lymphocytes harbor a common defect in assembly of N-acetyl-D-glucosamine inositol phospholipid corresponding to that in class A Thy-1- murine lymphoma mutants.Semantic proximity Read ↗

Deficient biosynthesis of N-acetylglucosaminyl-phosphatidylinositol, the first intermediate of glycosyl phosphatidylinositol anchor biosynthesis, in cell lines established from patients with paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Phosphatidylinositol synthesis is essential in bloodstream form Trypanosoma brucei.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.