Growth rate effects of mutations conferring streptomycin-dependence and of ancillary mutations in the rpsL gene of Escherichia coli: implications for the clustering (hypermutation) hypothesis for spontaneous mutation.

Abstract excerpt

Colonies of newly arising streptomycin-dependent (SmD) mutants frequently contain a high proportion of cells with additional mutations (ancillary mutations) in the same gene (rpsL). The ancillary mutations appear to have arisen at a rate greatly above expectation. To better estimate this rate it is necessary to allow for any selective advantage conferred by the ancillary mutations. We have previously measured...

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