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Article

Activation of secondary metabolite-biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus.

The Journal of antibiotics - 1 Dec 2009

Tanaka Yukinori, Tokuyama Shinji, Ochi Kozo

Abstract excerpt

Unlike other Streptomyces spp., the streptomycin producer Streptomyces griseus IFO13189 shows emergence of a small fraction of rsmG and rpsL mutants among spontaneous low- or high-level streptomycin-resistant mutants. rsmG, but not rpsL, mutants showed greater ability (two- to threefold) to produce streptomycin, accompanied by enhanced transcription of metK and strR, together with streptomycin biosynthetic genes,...

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Identifiers

PMID: 19816520
DOI: 10.1038/ja.2009.97

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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