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Article

Translational errors as the cause of mutations in Escherichia coli.

Molecular & general genetics : MGG - 1 Feb 1992

Boe L

Abstract excerpt

The present work suggests that a significant proportion of spontaneous mutations in Escherichia coli are the result of translational errors. This idea is supported by the following observations: (i) Streptomycin can induce the formation of auxotrophic mutants in streptomycin-sensitive cells, but not in rpsL mutants resistant to streptomycin, and (ii) strains having hyperaccurate ribosomes (rpsL999 and rpsL1204...

Topics

Alleles
Drug Resistance, Microbial
Escherichia coli
Escherichia coli Proteins
Genes, Bacterial
Kinetics
Mutation
Nalidixic Acid
Protein Biosynthesis
Ribosomal Protein S9
Ribosomes
Rifampin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Species Specificity

Streptomycin

Source

Identifiers

PMID: 1538699
DOI: 10.1007/BF00292717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1538699-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Translational errors as the cause of mutations in Escherichia coli.PMID 1538699Read ↗

The frequency of translational misreading errors in E. coli is largely determined by tRNA competition.Semantic proximity Read ↗

Processivity errors of gene expression in Escherichia coli.Semantic proximity Read ↗

Escherichia coli cells bearing a ribosomal ambiguity mutation in rpsD have a mutator phenotype that correlates with increased mistranslation.Semantic proximity Read ↗

Mutant sequences in the rpsL gene of Escherichia coli B/r: mechanistic implications for spontaneous and ultraviolet light mutagenesis.Semantic proximity Read ↗

Mistranslation and genetic variability: the effect of streptomycin.Semantic proximity Read ↗

Growth rate effects of mutations conferring streptomycin-dependence and of ancillary mutations in the rpsL gene of Escherichia coli: implications for the clustering (hypermutation) hypothesis for spontaneous mutation.Semantic proximity Read ↗

Mistranslation induced by streptomycin provokes a RecABC/RuvABC-dependent mutator phenotype in Escherichia coli cells.Semantic proximity Read ↗

Evidence for demand-regulation of ribosome accumulation in E coli.Semantic proximity Read ↗

Mechanisms of streptomycin resistance: selection of mutations in the 16S rRNA gene conferring resistance.Semantic proximity Read ↗

Translational misreading: a tRNA modification counteracts a +2 ribosomal frameshift.Semantic proximity Read ↗

Hyperaccurate and error-prone ribosomes exploit distinct mechanisms during tRNA selection.Semantic proximity Read ↗

Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium.Semantic proximity Read ↗

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