Article
Characterization of vincristine-resistant HOB1 lymphoma cell line showing the classical MDR phenotype and altered expression of membrane glycoproteins.
Oncology - 1 Jan 2000
Lee W P, Lee C L
Abstract excerpt
A multidrug-resistant (MDR) cell line isolated from HOB1 lymphoma cells was characterized. The MDR phenotype in this cell line was typified by resistance to vincristine with varying degrees of cross-resistance to Adriamycin, colcemid and actinomycin D. Decreased intracellular [3H]vincristine with...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents
- Blotting, Northern
- Blotting, Southern
- Blotting, Western
- Carbon Radioisotopes
- Carrier Proteins
- Cell Line
- Cell Survival
- Chromosome Mapping
- Chromosomes, Human, Pair 7
- DNA, Complementary
- DNA, Neoplasm
- Drug Resistance
- Electrophoresis, Polyacrylamide Gel
- Gene Expression
- Glucose
- Humans