Article
Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors.
Blood - 1 Mar 1998
Mickley L A, Lee J S, Weng Z, Zhan Z, Alvarez M, Wilson W, Bates S E, Fojo T
Abstract excerpt
By using RNase protection analysis, residues 2677 and 2995 of MDR-1 were identified as sites of genetic polymorphism. Through use of oligonucleotide hybridization, the genomic content and expression of individual MDR-1 alleles were examined in normal tissues, unselected and drug selected cell lin...
Topics
- Alleles
- Antineoplastic Agents
- Base Sequence
- Burkitt Lymphoma
- DNA, Neoplasm
- Drug Resistance, Neoplasm
- Genes, MDR
- Humans
- Lymphoma
- Molecular Sequence Data
- Nucleic Acid Hybridization
- Oligonucleotides
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Tumor Cells, Cultured
- Vincristine