Allelic loss on chromosomes 4q and 16q in hepatocellular carcinoma: association with elevated alpha-fetoprotein production.

doi:10.1053/gast.1996.v110.pm8536855

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Article

Allelic loss on chromosomes 4q and 16q in hepatocellular carcinoma: association with elevated alpha-fetoprotein production.

Gastroenterology - 1 Jan 1996

Yeh S H, Chen P J, Lai M Y, Chen D S

Abstract excerpt

BACKGROUND & AIMS: In human hepatocellular carcinoma, restriction fragment length polymorphism analysis has shown frequent allelic loss on chromosomes 4q and 16q. To better define the commonly affected region for further positional cloning of the putative tumor-suppressor genes contained in these...

Topics

Alleles
Carcinoma, Hepatocellular
Chromosome Mapping
Chromosomes, Human, Pair 16
Chromosomes, Human, Pair 4
Heterozygote
Humans
Liver Neoplasms
Microsatellite Repeats
alpha-Fetoproteins

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