Article
Methylation of the mouse M-lysozyme downstream enhancer inhibits heterotetrameric GABP binding.
Nucleic acids research - 11 Dec 1995
Nickel J, Short M L, Schmitz A, Eggert M, Renkawitz R
Abstract excerpt
Expression of the mouse M-lysozyme gene is a specific marker for the differentiation of macrophage/granulocyte cell lineages. Analysis of the mechanisms regulating M-lysozyme gene expression revealed an enhancer element in the 3'-flanking region of the gene, termed the M-lysozyme downstream enhancer (MLDE). Here we demonstrate that the nuclear factors binding to MLDE are present in all tested myeloid and...
Topics
- Animals
- Base Sequence
- Cell Line
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- GA-Binding Protein Transcription Factor
- Gene Expression Regulation, Enzymologic
- Methylation
- Mice
- Molecular Sequence Data
- Muramidase