Article
Identification of factors mediating the developmental regulation of the early acting -3.9 kb chicken lysozyme enhancer element.
Nucleic acids research - 15 Nov 2001
Lefevre P, Kontaraki J, Bonifer C
Abstract excerpt
The chicken lysozyme gene -3.9 kb enhancer forms a DNase I hypersensitive site (DHS) early in macrophage differentiation, but not in more primitive multipotent myeloid precursor cells. A nucleosome becomes precisely positioned across the enhancer in parallel with DHS formation. In transfection assays, the 5'-part of the -3.9 kb element has ubiquitous enhancer activity. The 3'-part has no stimulatory activity, but...
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