Article
Evolution of gene regulation as revealed by differential regulation of the chicken lysozyme transgene and the endogenous mouse lysozyme gene in mouse macrophages.
European journal of biochemistry - 15 Nov 1994
Bonifer C, Bosch F X, Faust N, Schuhmann A, Sippel A E
Abstract excerpt
Lysozyme gene expression is a marker for macrophage differentiation in vertebrates. We have previously shown that expression of the complete chicken lysozyme gene domain in macrophages of transgenic mice is directly correlated to the copy number of integrated transgenes. Thus, the chicken lysozym...
Topics
- Animals
- Animals, Genetically Modified
- Biological Evolution
- Cells, Cultured
- Chickens
- Gene Expression Regulation, Enzymologic
- Lipopolysaccharides
- Macrophages
- Mice
- Muramidase
- Mutation
- Sequence Deletion
- Species Specificity
- Transcriptional Activation