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Article

Human fetal globin gene expression is regulated by LYAR

4 Aug 2014

Abstract excerpt

Human globin gene expression during development is modulated by transcription factors in a stage-dependent manner. However, the mechanisms controlling the process are still largely unknown. In this study, we found that a nuclear protein, LYAR (human homologue of mouse Ly-1 antibody reactive clone) directly interacted with the methyltransferase PRMT5 which triggers the histone H4 Arg3 symmetric dimethylation...

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PMID: 25092918
DOI: 10.1093/nar/gku718

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