Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transformation of a novel direct-repeat repressor element into a promoter and enhancer by multimerisation.

Nucleic acids research - 11 Apr 1992

Chang K C, Hansen E, Jaenicke T, Goldspink G, Butterworth P

Abstract excerpt

Studies on the regulation of interferon (IFN) responsive genes have mainly been centred on the highly conserved IFN stimulated responsive elements (ISREs) which can mediate type I and II IFN inducibility. To date little is known about other functional cis-acting regulatory motifs in IFN responsive genes. We report here on the identification of a repressor element in the human MxA gene defined to a 19 base pair...

Topics

Base Sequence
Cell Line
Enhancer Elements, Genetic
Gene Expression Regulation
Humans
Interferons
Molecular Sequence Data
Mutagenesis
Phenotype
Promoter Regions, Genetic
Regulatory Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

Simian virus 40

Source

Open in PubMed Open full text

Identifiers

PMID: 1374558
DOI: 10.1093/nar/20.7.1669
PMCID: PMC312254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1374558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transformation of a novel direct-repeat repressor element into a promoter and enhancer by multimerisation.PMID 1374558Read ↗

A novel interferon-inducible domain: structural and functional analysis of the human interferon regulatory factor 1 gene promoter.Semantic proximity Read ↗

Transcriptional regulation of interferon‐stimulated genesSemantic proximity Read ↗

Transcription factors induced by interferons alpha and gamma.Semantic proximity Read ↗

Methylation of the mouse M-lysozyme downstream enhancer inhibits heterotetrameric GABP binding.Semantic proximity Read ↗

The Human Interferon-inducible Protein, IFI 16, Is a Repressor of TranscriptionSemantic proximity Read ↗

Specific binding of high-mobility-group I (HMGI) protein and histone H1 to the upstream AT-rich region of the murine beta interferon promoter: HMGI protein acts as a potential antirepressor of the promoter.Semantic proximity Read ↗

Repression by a differentiation-specific factor of the human cytomegalovirus enhancer.Semantic proximity Read ↗

Activation of IFN-<i>β</i>element by IRF-1 requires a post-translational event in addition to IRF-1 synthesisSemantic proximity Read ↗

Analysis of the defect in IFN-gamma induction of MHC class II genes in G1B cells: identification of a novel and functionally critical leucine-rich motif (62-LYLYLQL-68) in the regulatory factor X 5 transcription factor.Semantic proximity Read ↗

A non-classical ISRE/ISGF3 pathway mediates induction of RANTES gene transcription by type I IFNs.Semantic proximity Read ↗

Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.Semantic proximity Read ↗

A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.