Article
Binding properties of the naturally occurring human 5-HT1A receptor variant with the Ile28Val substitution in the extracellular domain.
Naunyn-Schmiedeberg's archives of pharmacology - 1 Oct 1995
Brüss M, Bühlen M, Erdmann J, Göthert M, Bönisch H
Abstract excerpt
The cDNA from a schizophrenic patient heterozygous for a mutation of the 5-HT1A receptor gene was used to clone the variant and wild-type DNA into a eukaryotic expression vector. The mutation was characterized by a base pair substitution (A --> G) at the first position of codon 28, leading to an Ile --> Val amino acid exchange. COS-7 cells were transfected with the cDNA of either the wild type or the variant...
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