Binding properties of the naturally occurring human 5-HT1A receptor variant with the Ile28Val substitution in the extracellular domain.

doi:10.1007/BF00172786

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Article

Binding properties of the naturally occurring human 5-HT1A receptor variant with the Ile28Val substitution in the extracellular domain.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Oct 1995

Brüss M, Bühlen M, Erdmann J, Göthert M, Bönisch H

Abstract excerpt

The cDNA from a schizophrenic patient heterozygous for a mutation of the 5-HT1A receptor gene was used to clone the variant and wild-type DNA into a eukaryotic expression vector. The mutation was characterized by a base pair substitution (A --> G) at the first position of codon 28, leading to an...

Topics

8-Hydroxy-2-(di-n-propylamino)tetralin
Base Sequence
Cells, Cultured
Humans
Molecular Sequence Data
Mutation
Receptors, Serotonin
Structure-Activity Relationship

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