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Article

Conversion of the human 5-HT1D beta serotonin receptor to the rat 5-HT1B ligand-binding phenotype by Thr355Asn site directed mutagenesis.

Biochemical pharmacology - 17 Nov 1992

Metcalf M A, McGuffin R W, Hamblin M W

Abstract excerpt

The human 5-HT1D beta serotonin receptor and its rat homolog (also called the 5-HT1B receptor) share 93% amino acid identity, yet display markedly different pharmacological specificities. Comparison of deduced amino acid sequences among these and other recently cloned receptors suggested that this phenotypic difference might be attributable to a single human threonine355/rat asparagine351 amino acid difference in...

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Identifiers

PMID: 1449511
DOI: 10.1016/0006-2952(92)90092-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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