Conversion of the human 5-HT1D beta serotonin receptor to the rat 5-HT1B ligand-binding phenotype by Thr355Asn site directed mutagenesis.

doi:10.1016/0006-2952(92)90092-w

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Article

Conversion of the human 5-HT1D beta serotonin receptor to the rat 5-HT1B ligand-binding phenotype by Thr355Asn site directed mutagenesis.

Biochemical pharmacology - 17 Nov 1992

Metcalf M A, McGuffin R W, Hamblin M W

Abstract excerpt

The human 5-HT1D beta serotonin receptor and its rat homolog (also called the 5-HT1B receptor) share 93% amino acid identity, yet display markedly different pharmacological specificities. Comparison of deduced amino acid sequences among these and other recently cloned receptors suggested that thi...

Topics

Amino Acid Sequence
Animals
Asparagine
Binding Sites
Cell Line
Humans
Molecular Sequence Data
Mutagenesis, Site-Directed
Phenotype
Pindolol
Rats
Receptors, Serotonin
Recombinant Proteins
Threonine

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