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Article

Genetic variation in human 5-HT receptors: potential pathogenetic and pharmacological role.

Annals of the New York Academy of Sciences - 15 Dec 1998

Göthert M, Propping P, Bönisch H, Brüss M, Nöthen M M

Abstract excerpt

Mutation screening identified variants of h5-HT1A (Gly-22-Ser, Ile-28-Val, Arg-219-Leu), h5-HT1B (Phe-124-Cys), h5-HT2A (Thr-25-Asn, His-452-Tyr), h5-HT2C (Cys-23-Ser) and h5-HT7 (Thr-92-Lys, Pro-279-Leu) receptors. Screening of h5-HT1D, h5-ht1e, h5-ht1f and h5-ht5 receptor genes failed to detect any significant mutations. No differences in radioligand binding properties were observed between the h5-HT1A...

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Source

Identifiers

PMID: 9928235
DOI: 10.1111/j.1749-6632.1998.tb10169.x

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