Article
Pharmacological and electrophysiological properties of the naturally occurring Pro391Arg variant of the human 5-HT3A receptor.
Pharmacogenetics - 1 Mar 2004
Kurzwelly Delia, Barann Martin, Kostanian Arevat, Combrink Sandra, Bönisch Heinz, Göthert Manfred, Brüss Michael
Abstract excerpt
The 5-HT3A receptor, a ligand-gated ion channel, is involved in pain pathways, nausea and emesis, and irritable bowel syndrome, and may play a role in the pathogenesis of psychiatric diseases such as schizophrenia and depression. Recently, a naturally occurring variation (ProArg) in the second intracellular loop of the human (h) 5-HT3A receptor was identified in a schizophrenic patient. Because the substitution...
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