Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The naturally occurring Arg219Leu variant of the human 5-HT1A receptor: impairment of signal transduction.

Pharmacogenetics and genomics - 1 Apr 2005

Brüss Michael, Kostanian Arevat, Bönisch Heinz, Göthert Manfred

Abstract excerpt

The present study in transfected HEK293 cells aimed to investigate whether the pharmacological and/or transductional properties of the naturally occurring Arg219Leu variant (VAR) in the third intracellular loop of the h5-HT1A receptor differ from those of the wild-type receptor. Binding of [3H]8-hydroxy-2-(di-n-propylamino)tetraline ([H]8-OH-DPAT) and of [35S]GTPgammaS to membranes, as well as inhibition of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Anxiety Agents
Share to Colforsin
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inhibitory Concentration 50

Share to Leucine

Share to Piperazines

Share to Receptor, Serotonin, 5-HT1A

Share to Serotonin Antagonists

Source

Identifiers

PMID: 15864118
DOI: 10.1097/01213011-200504000-00009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The naturally occurring Arg219Leu variant of the human 5-HT1A receptor: impairment of signal transduction.PMID 15864118Read ↗

Pharmacological and electrophysiological properties of the naturally occurring Pro391Arg variant of the human 5-HT3A receptor.Semantic proximity Read ↗

Binding properties of the naturally occurring human 5-HT1A receptor variant with the Ile28Val substitution in the extracellular domain.Semantic proximity Read ↗

Genetic variation in human 5-HT receptors: potential pathogenetic and pharmacological role.Semantic proximity Read ↗

Characterization of the naturally occurring Arg344His variant of the human 5-HT 3A receptor.Semantic proximity Read ↗

Decreased agonist, but not antagonist, binding to the naturally occurring Thr92Lys variant of the h5-HT7(a) receptor.Semantic proximity Read ↗

Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression.Semantic proximity Read ↗

Pharmacological characterization of tegaserod at the wild type and 124Cys variant of the human 5-HT1B receptor.Semantic proximity Read ↗

The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution.Semantic proximity Read ↗

Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.Semantic proximity Read ↗

The recombinant 5-HT1A receptor: G protein coupling and signalling pathways.Semantic proximity Read ↗

New insights into the human 5-HT4 receptor binding site: exploration of a hydrophobic pocket.Semantic proximity Read ↗

Attenuated PLD1 association and signalling at the H452Y polymorphic form of the 5-HT(2A) receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.