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Article

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype.

Pharmacogenetics - 1 Oct 1991

Tyndale R, Aoyama T, Broly F, Matsunaga T, Inaba T, Kalow W, Gelboin H V, Meyer U A, Gonzalez F J

Abstract excerpt

A variant CYP2D6(C) P450 protein was found in a liver characterized by deficient microsomal metabolism of bufuralol and sparteine, prototypical substrates for the debrisoquine-sparteine drug oxidation polymorphism. This protein was present at decreased levels in liver and had a slightly different relative mobility on SDS-polyacrylamide gels. The cDNA cloning and sequencing of the variant, designated CYP2D6(C),...

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PMID: 1844820
DOI: 10.1097/00008571-199110000-00005

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Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype.PMID 1844820Read ↗

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