Article
Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype.
Pharmacogenetics - 1 Oct 1991
Tyndale R, Aoyama T, Broly F, Matsunaga T, Inaba T, Kalow W, Gelboin H V, Meyer U A, Gonzalez F J
Abstract excerpt
A variant CYP2D6(C) P450 protein was found in a liver characterized by deficient microsomal metabolism of bufuralol and sparteine, prototypical substrates for the debrisoquine-sparteine drug oxidation polymorphism. This protein was present at decreased levels in liver and had a slightly different...
Topics
- Alleles
- Base Sequence
- Codon
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- DNA Probes
- Ethanolamines
- Gene Library
- Genetic Variation
- Genetic Vectors
- Humans
- Introns
- Kinetics
- Liver
- Lysine
- Microsomes, Liver
- Mixed Function Oxygenases
- Molecular Sequence Data