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Article

Theiler's virus infection induces a specific cytotoxic T lymphocyte response.

Cellular immunology - 1 Dec 1991

Pena Rossi C, McAllister A, Fiette L, Brahic M

Abstract excerpt

Theiler's virus, a murine picornavirus, persists in the central nervous system of susceptible mouse strains and causes chronic inflammation and primary demyelination. One of the current hypotheses is that demyelination is, at least in part, mediated by virus-specific cytotoxic T lymphocytes (CTL). However, it is generally assumed that picornaviruses do not induce CTL. In point of fact, their existence has only...

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Identifiers

PMID: 1934074
DOI: 10.1016/0008-8749(91)90158-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Theiler's virus infection induces a specific cytotoxic T lymphocyte response.PMID 1934074Read ↗

The infection of mouse by Theiler's virus: from genetics to immunology.Semantic proximity Read ↗

VP1 and VP2 capsid proteins of Theiler's virus are targets of H-2D-restricted cytotoxic lymphocytes in the central nervous system of B10 mice.Semantic proximity Read ↗

Determinants of persistence and demyelination of the DA strain of Theiler's virus are found only in the VP1 gene.Semantic proximity Read ↗

Accumulation of T-Cells with Selected T-Cell Receptors in the Brains of Japanese Encephalitis Virus-Infected MiceSemantic proximity Read ↗

Clearance of Theiler's virus infection depends on the ability to generate a CD8 <sup>+</sup> T cell response against a single immunodominant viral peptideSemantic proximity Read ↗

Susceptibility to measles virus-induced encephalitis in mice correlates with impaired antigen presentation to cytotoxic T lymphocytesSemantic proximity Read ↗

Selection of CTL escape mutants in mice infected with a neurotropic coronavirus: quantitative estimate of TCR diversity in the infected central nervous system.Semantic proximity Read ↗

Chimeric Theiler's virus with altered tropism for the central nervous system.Semantic proximity Read ↗

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope.Semantic proximity Read ↗

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Theiler's virus induces the MIP-2 chemokine (CXCL2) in astrocytes from genetically susceptible but not from resistant mouse strains.Semantic proximity Read ↗

H-2D(b-/-) mice are susceptible to persistent infection by Theiler's virus.Semantic proximity Read ↗

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