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Article

Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene.

Microbial pathogenesis - 1 Jan 1990

Rodriguez M, Kenny J J, Thiemann R L, Woloschak G E

Abstract excerpt

Intracerebral infection with Theiler's murine encephalomyelitis virus produces chronic immune-mediated demyelination in susceptible strains of mice. We examined the role of Ig in the pathogenesis of demyelination. In susceptible SJL/J mice (H-2s), suppression of B cell responses with IgG fraction...

Topics

Animals
Antibodies, Anti-Idiotypic
Demyelinating Diseases
Dysgammaglobulinemia
Enterovirus Infections
Enzyme-Linked Immunosorbent Assay
Gene Expression
Immunoglobulin G
Immunoglobulin M
Immunologic Deficiency Syndromes
Maus Elberfeld virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Source

Identifiers

PMID: 2333032
DOI: 10.1016/0882-4010(90)90005-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2333032-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene.PMID 2333032Read ↗

CD8-deficient SJL mice display enhanced susceptibility to Theiler's virus infection and increased demyelinating pathology.Semantic proximity Read ↗

The infection of mouse by Theiler's virus: from genetics to immunology.Semantic proximity Read ↗

VP1 and VP2 capsid proteins of Theiler's virus are targets of H-2D-restricted cytotoxic lymphocytes in the central nervous system of B10 mice.Semantic proximity Read ↗

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope.Semantic proximity Read ↗

Human class I major histocompatibility complex transgene prevents virus-induced demyelination in susceptible mutant B10.D2dml mice.Semantic proximity Read ↗

Hemagglutinin-esterase-specific monoclonal antibodies alter the neuropathogenicity of mouse hepatitis virus.Semantic proximity Read ↗

The xid mutation diminishes memory B cell generation but does not affect somatic hypermutation and selection.Semantic proximity Read ↗

Clearance of Theiler's virus infection depends on the ability to generate a CD8 <sup>+</sup> T cell response against a single immunodominant viral peptideSemantic proximity Read ↗

The xid mutation plays an important role in delayed development of murine acquired immunodeficiency syndrome.Semantic proximity Read ↗

Bone marrow chimeras reveal non-H-2 hematopoietic control of susceptibility to Theiler's virus persistent infection.Semantic proximity Read ↗

Viral hyperinfection of the central nervous system and high mortality after hematopoietic stem cell transplantation for treatment of Theiler's murine encephalomyelitis virus-induced demyelinating disease.Semantic proximity Read ↗

Significant association between the skewed natural antibody repertoire of Xid mice and resistance to Trypanosoma cruzi infection.Semantic proximity Read ↗

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