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Article

Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene.

Microbial pathogenesis - 1 Jan 1990

Rodriguez M, Kenny J J, Thiemann R L, Woloschak G E

Abstract excerpt

Intracerebral infection with Theiler's murine encephalomyelitis virus produces chronic immune-mediated demyelination in susceptible strains of mice. We examined the role of Ig in the pathogenesis of demyelination. In susceptible SJL/J mice (H-2s), suppression of B cell responses with IgG fraction of goat anti-mu (anti-mu IgG) from birth resulted in increased numbers and severity of demyelinating lesions in the...

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Source

Identifiers

PMID: 2333032
DOI: 10.1016/0882-4010(90)90005-b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene.PMID 2333032Read ↗

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The xid mutation diminishes memory B cell generation but does not affect somatic hypermutation and selection.Semantic proximity Read ↗

Clearance of Theiler's virus infection depends on the ability to generate a CD8 <sup>+</sup> T cell response against a single immunodominant viral peptideSemantic proximity Read ↗

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Significant association between the skewed natural antibody repertoire of Xid mice and resistance to Trypanosoma cruzi infection.Semantic proximity Read ↗

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