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Article

High-resolution physical and functional mapping of the template adjacent DNA binding site in catalytically active telomerase.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2007

Romi Erez, Baran Nava, Gantman Marina, Shmoish Michael, Min Bosun, Collins Kathleen, Manor Haim

Abstract excerpt

Telomerase is a cellular reverse transcriptase, which utilizes an integral RNA template to extend single-stranded telomeric DNA. We used site-specific photocrosslinking to map interactions between DNA primers and the catalytic protein subunit (tTERT) of Tetrahymena thermophila telomerase in functional enzyme complexes. Our assays reveal contact of the single-stranded DNA adjacent to the primer-template hybrid and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17494734
DOI: 10.1073/pnas.0703157104
PMCID: PMC1885581

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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