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Article

Functional reconstitution of wild-type and mutant Tetrahymena telomerase.

Genes & development - 1 Mar 1994

Autexier C, Greider C W

Abstract excerpt

Telomerase is a ribonucleoprotein that catalyzes telomere elongation in vitro and in vivo. The 159-nucleotide RNA component of Tetrahymena telomerase contains the sequence 5'-CAACCCCAA-3' ("template region"), which serves as a template for the addition of the sequence d(TTGGGG)n to Tetrahymena telomeres. To dissect the Tetrahymena telomerase enzyme mechanism, we developed a functional in vitro reconstitution...

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Source

Identifiers

PMID: 7523243
DOI: 10.1101/gad.8.5.563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional reconstitution of wild-type and mutant Tetrahymena telomerase.PMID 7523243Read ↗

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A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.Semantic proximity Read ↗

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Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase.Semantic proximity Read ↗

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs.Semantic proximity Read ↗

High-resolution physical and functional mapping of the template adjacent DNA binding site in catalytically active telomerase.Semantic proximity Read ↗

Yeast telomerase is specialized for C/A-rich RNA templates.Semantic proximity Read ↗

Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA.Semantic proximity Read ↗

Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme.Semantic proximity Read ↗

Biological and biochemical functions of RNA in the tetrahymena telomerase holoenzyme.Semantic proximity Read ↗

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