Article
Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif.
Cell - 29 Jul 1994
Fabre E, Boelens W C, Wimmer C, Mattaj I W, Hurt E C
Abstract excerpt
An essential yeast protein, Nup145p, is identified via its genetic interaction with the nucleoporin Nsp1p. Nup145p contains GLFG repeats and localizes to nuclear pores. Depletion of Nup145p in vivo leads rapidly to nuclear retention of polyadenylated RNAs and more slowly to cytoplasmic accumulati...
Topics
- Amino Acid Sequence
- Cloning, Molecular
- Conserved Sequence
- Fungal Proteins
- Gene Expression
- Genes, Fungal
- Genes, Lethal
- Membrane Proteins
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Nuclear Envelope
- Nuclear Pore Complex Proteins
- Nuclear Proteins
- RNA, Fungal
- RNA, Messenger
- RNA-Binding Proteins
- Recombinant Fusion Proteins