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Article

Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif.

Cell - 29 Jul 1994

Fabre E, Boelens W C, Wimmer C, Mattaj I W, Hurt E C

Abstract excerpt

An essential yeast protein, Nup145p, is identified via its genetic interaction with the nucleoporin Nsp1p. Nup145p contains GLFG repeats and localizes to nuclear pores. Depletion of Nup145p in vivo leads rapidly to nuclear retention of polyadenylated RNAs and more slowly to cytoplasmic accumulation of a nuclear reporter protein. A stretch of 140 amino acids within Nup145p is conserved in two other yeast...

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Identifiers

PMID: 8044840
DOI: 10.1016/0092-8674(94)90297-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif.PMID 8044840Read ↗

Defining the essential functional regions of the nucleoporin Nup145p.Semantic proximity Read ↗

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The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function.Semantic proximity Read ↗

Yeast nucleoporin mutants are defective in pre-tRNA splicing.Semantic proximity Read ↗

Npp106p, a Schizosaccharomyces pombe nucleoporin similar to Saccharomyces cerevisiae Nic96p, functionally interacts with Rae1p in mRNA export.Semantic proximity Read ↗

Mutations affecting spindle pole body and mitotic exit network function are synthetically lethal with a deletion of the nucleoporin NUP1 in S. cerevisiae.Semantic proximity Read ↗

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