Article
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression.
Molecular and cellular biology - 1 Jun 1995
Owen-Schaub L B, Zhang W, Cusack J C, Angelo L S, Santee S M, Fujiwara T, Roth J A, Deisseroth A B, Zhang W W, Kruzel E
Abstract excerpt
Fas/APO-1 is a cell surface protein known to trigger apoptosis upon specific antibody engagement. Because wild-type p53 can activate transcription as well as induce apoptosis, we queried whether p53 might upregulate Fas/APO-1. To explore this possibility, we examined human p53-null (H358 non-small-cell lung adenocarcinoma and K562 erythroleukemia) and wild-type p53-containing (H460 non-small-cell lung...
Topics
- Adenocarcinoma
- Antigens, Surface
- Apoptosis
- Humans
- Leukemia, Erythroblastic, Acute
- Lung Neoplasms
- Mutation
- RNA, Messenger
- Temperature
- Transcription, Genetic
- Tumor Cells, Cultured