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Article

The functional integration of a polytopic membrane protein of Escherichia coli is dependent on the bacterial signal-recognition particle.

European journal of biochemistry - 1 Nov 1995

Macfarlane J, Müller M

Abstract excerpt

In eukaryotes, the cotranslational targeting of proteins to the endoplasmic reticular membrane is initially mediated by the signal-recognition particle (SRP), a ribonucleoprotein complex consisting of the 7SL RNA and six protein subunits. Since the discovery of sequence homology between (a) the Escherichia coli 4.5S RNA (Ffs) and 7SL RNA, and (b) the E. coli P48 (Ffh) and SRP 54-kDa subunit, more evidence has...

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Identifiers

PMID: 8521840
DOI: 10.1111/j.1432-1033.1995.766_3.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The functional integration of a polytopic membrane protein of Escherichia coli is dependent on the bacterial signal-recognition particle.PMID 8521840Read ↗

Functional integration of a polytopic membrane protein of E. coli requires the bacterial signal recognition particle.Semantic proximity Read ↗

An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle.Semantic proximity Read ↗

The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins.Semantic proximity Read ↗

The signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting.Semantic proximity Read ↗

Functional analysis of the signal recognition particle in Escherichia coli by characterization of a temperature-sensitive ffh mutant.Semantic proximity Read ↗

SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.Semantic proximity Read ↗

Conserved but nonessential interaction of SRP RNA with translation factor EF-G.Semantic proximity Read ↗

Insertion of the polytopic membrane protein MalF is dependent on the bacterial secretion machinery.Semantic proximity Read ↗

SecA is required for the insertion of inner membrane proteins targeted by the Escherichia coli signal recognition particle.Semantic proximity Read ↗

A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins.Semantic proximity Read ↗

Evolutionary conserved nucleotides within the E.coli 4.5S RNA are required for association with P48 in vitro and for optimal function in vivo.Semantic proximity Read ↗

SecA mediates cotranslational targeting and translocation of an inner membrane protein.Semantic proximity Read ↗

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