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Article

An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle.

Science (New York, N.Y.) - 23 Nov 1990

Poritz M A, Bernstein H D, Strub K, Zopf D, Wilhelm H, Walter P

Abstract excerpt

The signal recognition particle (SRP) plays a central role in directing the export of nascent proteins from the cytoplasm of mammalian cells. An SRP-dependent translocation machinery in bacteria has not been demonstrated in previous genetic and biochemical studies. Sequence comparisons, however, have identified (i) a gene in Escherichia coli (ffh) whose product is homologous to the 54-kilodalton subunit (SRP54)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1701272
DOI: 10.1126/science.1701272

Genes

SRP54

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle.PMID 1701272Read ↗

Functional analysis of the signal recognition particle in Escherichia coli by characterization of a temperature-sensitive ffh mutant.Semantic proximity Read ↗

The functional integration of a polytopic membrane protein of Escherichia coli is dependent on the bacterial signal-recognition particle.Semantic proximity Read ↗

Physiological basis for conservation of the signal recognition particle targeting pathway in Escherichia coli.Semantic proximity Read ↗

Conserved but nonessential interaction of SRP RNA with translation factor EF-G.Semantic proximity Read ↗

Substitution of fifty four homologue (Ffh) in Escherichia coli with the mammalian 54-kDa protein of signal-recognition particle.Semantic proximity Read ↗

Depletion of Escherichia coli 4.5S RNA leads to an increase in the amount of protein elongation factor EF-G associated with ribosomes.Semantic proximity Read ↗

Minimal functional structure of Escherichia coli 4.5 S RNA required for binding to elongation factor G.Semantic proximity Read ↗

The gene for the longest known Escherichia coli protein is a member of helicase superfamily II.Semantic proximity Read ↗

Characterization of conserved bases in 4.5S RNA of Escherichia coli by construction of new F' factors.Semantic proximity Read ↗

A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins.Semantic proximity Read ↗

Genetic screen yields mutations in genes encoding all known components of the Escherichia coli signal recognition particle pathway.Semantic proximity Read ↗

Molecular evolution of SRP cycle components: functional implications.Semantic proximity Read ↗

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