Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SecA is required for the insertion of inner membrane proteins targeted by the Escherichia coli signal recognition particle.

The Journal of biological chemistry - 26 Mar 1999

Qi H Y, Bernstein H D

Abstract excerpt

Recent work has demonstrated that the signal recognition particle (SRP) is required for the efficient insertion of many proteins into the Escherichia coli inner membrane (IM). Based on an analogy to eukaryotic SRP, it is likely that bacterial SRP binds to inner membrane proteins (IMPs) co-translationally and then targets them to protein transport channels ("translocons"). Here we present evidence that SecA, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Bacterial Outer Membrane Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Biological Transport

Share to Multidrug Resistance-Associated Proteins

Share to SEC Translocation Channels

Share to SecA Proteins

Share to Signal Recognition Particle

Share to Suppression, Genetic

Source

Identifiers

PMID: 10085146
DOI: 10.1074/jbc.274.13.8993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SecA is required for the insertion of inner membrane proteins targeted by the Escherichia coli signal recognition particle.PMID 10085146Read ↗

The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins.Semantic proximity Read ↗

SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein.Semantic proximity Read ↗

SecA mediates cotranslational targeting and translocation of an inner membrane protein.Semantic proximity Read ↗

A mutation in the Escherichia coli secY gene that produces distinct effects on inner membrane protein insertion and protein export.Semantic proximity Read ↗

Export of beta-lactamase is independent of the signal recognition particle.Semantic proximity Read ↗

Dynamic action of the Sec machinery during initiation, protein translocation and termination.Semantic proximity Read ↗

SecA protein: autoregulated initiator of secretory precursor protein translocation across the E. coli plasma membrane.Semantic proximity Read ↗

Synergistic insertion of two hydrophobic regions drives Sec-independent membrane protein assembly.Semantic proximity Read ↗

Effect of OmpA signal peptide mutations on OmpA secretion, synthesis, and assembly.Semantic proximity Read ↗

SecA interacts with ribosomes in order to facilitate posttranslational translocation in bacteria.Semantic proximity Read ↗

The functional integration of a polytopic membrane protein of Escherichia coli is dependent on the bacterial signal-recognition particle.Semantic proximity Read ↗

Physiological basis for conservation of the signal recognition particle targeting pathway in Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.