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Article

The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins.

Cell - 24 Jan 1997

Ulbrandt N D, Newitt J A, Bernstein H D

Abstract excerpt

E. coli homologs of the signal recognition particle (SRP) and its receptor are essential for viability, but their role in protein export is unclear. To elucidate their function, we devised a genome-wide screen to identify genes that encode SRP substrates. Inhibition of the SRP pathway sharply blocked the membrane insertion of several polytopic inner membrane proteins (IMPs) that were predicted to be SRP...

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Identifiers

PMID: 9008159
DOI: 10.1016/s0092-8674(00)81839-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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